Transitional premonocytes emerge in the periphery for host defense against bacterial infections

• Main Authors: Teh, Ye Chean, Chooi, Ming Yao, Liu, Dehua, Kwok, Immanuel, Lai, Ghee Chuan, Ow Yong, Liyana Ayub, Ng, Melissa, Li, Jackson L. Y., Tan, Yingrou, Evrard, Maximilien, Tan, Leonard, Liong, Ka Hang, Leong, Keith, Goh, Chi Ching, Chan, Andrew Y. J., Nurhidaya Binte Shadan, Mantri, Chinmay Kumar, Hwang, You Yi, Cheng, Hui, Cheng, Tao, Yu, Weimiao, Tey, Hong Liang, Larbi, Anis, St John, Ashley, Angeli, Veronique, Ruedl, Christiane, Lee, Bernett, Ginhoux, Florent, Chen, Swaine L., Ng, Lai Guan, Ding, Jeak Ling, Chong, Shu Zhen
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Science::Biological sciences; Bacterial Infections; Host Defense
• Online Access: https://hdl.handle.net/10356/164367
• Institution: Nanyang Technological University

Circulating Ly6Chi monocytes often undergo cellular death upon exhaustion of their antibacterial effector functions, which limits their capacity for subsequent macrophage differentiation. This shrouds the understanding on how the host replaces the tissue-resident macrophage niche effectively during...