Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor

• Main Authors: Personnaz, Jean, Piccolo, Enzo, Dortignac, Alizée, Iacovoni, Jason S., Mariette, Jérôme, Rocher, Vincent, Polizzi, Arnaud, Batut, Aurélie, Deleruyelle, Simon, Bourdens, Lucas, Delos, Océane, Combes-Soia, Lucie, Paccoud, Romain, Moreau, Elsa, Martins, Frédéric, Clouaire, Thomas, Benhamed, Fadila, Montagner, Alexandra, Wahli, Walter, Schwabe, Robert F., Yart, Armelle, Castan-Laurell, Isabelle, Bertrand-Michel, Justine, Burlet-Schiltz, Odile, Postic, Catherine, Denechaud, Pierre-Damien, Moro, Cédric, Legube, Gaelle, Lee, Chih-Hao, Guillou, Hervé, Valet, Philippe, Dray, Cédric, Pradère, Jean-Philippe
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Fatty Liver; Lipid Metabolisms
• Online Access: https://hdl.handle.net/10356/164369
• Institution: Nanyang Technological University

Dysregulations of lipid metabolism in the liver may trigger steatosis progression, leading to potentially severe clinical consequences such as nonalcoholic fatty liver diseases (NAFLDs). Molecular mechanisms underlying liver lipogenesis are very complex and fine-tuned by chromatin dynamics and multi...