Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion

Dexamethasone is widely used as an immunosuppressive therapy and recently as COVID-19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of iron-catalyzed necrosis, previously suggested to contribute to diseases such as acute kidney injury, myocardial infarction, an...

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Main Authors: von Mässenhausen, Anne, Gonzalez, Nadia Zamora, Maremonti, Francesca, Belavgeni, Alexia, Tonnus, Wulf, Meyer, Claudia, Beer, Kristina, Hannani, Monica T., Lau, Arthur, Peitzsch, Mirko, Hoppenz, Paul, Locke, Sophie, Chavakis, Triantafyllos, Kramann, Rafael, Muruve, Daniel A., Hugo, Christian, Bornstein, Stefan R., Linkermann, Andreas
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2023
Subjects:
Online Access:https://hdl.handle.net/10356/164371
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Institution: Nanyang Technological University
Language: English