Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion

• Main Authors: von Mässenhausen, Anne, Gonzalez, Nadia Zamora, Maremonti, Francesca, Belavgeni, Alexia, Tonnus, Wulf, Meyer, Claudia, Beer, Kristina, Hannani, Monica T., Lau, Arthur, Peitzsch, Mirko, Hoppenz, Paul, Locke, Sophie, Chavakis, Triantafyllos, Kramann, Rafael, Muruve, Daniel A., Hugo, Christian, Bornstein, Stefan R., Linkermann, Andreas
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2023
• 主題: Science::Medicine; Dexamethasones; Glucocorticoid Receptor
• 在線閱讀: https://hdl.handle.net/10356/164371
• 機構: Nanyang Technological University

Dexamethasone is widely used as an immunosuppressive therapy and recently as COVID-19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of iron-catalyzed necrosis, previously suggested to contribute to diseases such as acute kidney injury, myocardial infarction, an...