Activating nanomedicines with electromagnetic energy for deep-tissue induction of immunogenic cell death in cancer immunotherapy

Immunotherapy is an attractive approach for cancer therapy, while its antitumor efficacy is still limited, especially for non-immunogenic tumors. Nanomedicines can be utilized to convert the non-immunogenic "cold" tumors to immunogenic "hot" tumors via inducing immunogenic cell d...

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Main Authors: Wang, Fengshuo, Pu, Kanyi, Li, Jingchao
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2023
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Online Access:https://hdl.handle.net/10356/164393
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-1643932023-06-21T07:33:10Z Activating nanomedicines with electromagnetic energy for deep-tissue induction of immunogenic cell death in cancer immunotherapy Wang, Fengshuo Pu, Kanyi Li, Jingchao Lee Kong Chian School of Medicine (LKCMedicine) School of Chemistry, Chemical Engineering and Biotechnology Science::Chemistry Deep-Tissue Electromagnetic Energy Immunotherapy is an attractive approach for cancer therapy, while its antitumor efficacy is still limited, especially for non-immunogenic tumors. Nanomedicines can be utilized to convert the non-immunogenic "cold" tumors to immunogenic "hot" tumors via inducing immunogenic cell death (ICD), thereby promoting the antitumor immune response. Some nanomedicines that can produce local heat and reactive oxygen species upon the stimulation of electromagnetic energy are the main candidates for inducing the ICD effect. However, their applications are often restricted due to the poor tissue penetration depths of electromagnetic energy, such as light. By contrast, ultrasound, X-ray, alternating magnetic field, and microwave show excellent tissue penetration depths and thereby can be used for sonodynamic therapy, radiotherapy, magnetic hyperthermia therapy, and microwave ablation therapy, all of which can effectively induce ICD. Herein, the combination of deep-tissue electromagnetic energy with nanomedicines for inducing ICD and cancer immunotherapy are summarized. In particular, the designs of nanomedicines to amplify ICD effect in the presence of deep-tissue electromagnetic energy and sensitize tumors to various immunotherapies will be discussed. At the end of this review, a brief conclusion and discussion of current challenges and further perspectives in this subfield are provided. Submitted/Accepted version This study was financially supported by the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, the Science and Technology Commission of Shanghai Municipality (22ZR1401100, 22490760700, 20DZ2254900), and Fundamental Research Funds for the Central Universities (2232021A-05). 2023-01-18T08:56:50Z 2023-01-18T08:56:50Z 2022 Journal Article Wang, F., Pu, K. & Li, J. (2022). Activating nanomedicines with electromagnetic energy for deep-tissue induction of immunogenic cell death in cancer immunotherapy. Small Methods. https://dx.doi.org/10.1002/smtd.202201083 2366-9608 https://hdl.handle.net/10356/164393 10.1002/smtd.202201083 36316270 2-s2.0-85141366699 en Small Methods © 2022 Wiley-VCH GmbH. All rights reserved. This is the peer reviewed version of the following article: Wang, F., Pu, K. & Li, J. (2022). Activating nanomedicines with electromagnetic energy for deep-tissue induction of immunogenic cell death in cancer immunotherapy. Small Methods, which has been published in final form at https://doi.org/10.1002/smtd.202201083. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Deep-Tissue
Electromagnetic Energy
spellingShingle Science::Chemistry
Deep-Tissue
Electromagnetic Energy
Wang, Fengshuo
Pu, Kanyi
Li, Jingchao
Activating nanomedicines with electromagnetic energy for deep-tissue induction of immunogenic cell death in cancer immunotherapy
description Immunotherapy is an attractive approach for cancer therapy, while its antitumor efficacy is still limited, especially for non-immunogenic tumors. Nanomedicines can be utilized to convert the non-immunogenic "cold" tumors to immunogenic "hot" tumors via inducing immunogenic cell death (ICD), thereby promoting the antitumor immune response. Some nanomedicines that can produce local heat and reactive oxygen species upon the stimulation of electromagnetic energy are the main candidates for inducing the ICD effect. However, their applications are often restricted due to the poor tissue penetration depths of electromagnetic energy, such as light. By contrast, ultrasound, X-ray, alternating magnetic field, and microwave show excellent tissue penetration depths and thereby can be used for sonodynamic therapy, radiotherapy, magnetic hyperthermia therapy, and microwave ablation therapy, all of which can effectively induce ICD. Herein, the combination of deep-tissue electromagnetic energy with nanomedicines for inducing ICD and cancer immunotherapy are summarized. In particular, the designs of nanomedicines to amplify ICD effect in the presence of deep-tissue electromagnetic energy and sensitize tumors to various immunotherapies will be discussed. At the end of this review, a brief conclusion and discussion of current challenges and further perspectives in this subfield are provided.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Wang, Fengshuo
Pu, Kanyi
Li, Jingchao
format Article
author Wang, Fengshuo
Pu, Kanyi
Li, Jingchao
author_sort Wang, Fengshuo
title Activating nanomedicines with electromagnetic energy for deep-tissue induction of immunogenic cell death in cancer immunotherapy
title_short Activating nanomedicines with electromagnetic energy for deep-tissue induction of immunogenic cell death in cancer immunotherapy
title_full Activating nanomedicines with electromagnetic energy for deep-tissue induction of immunogenic cell death in cancer immunotherapy
title_fullStr Activating nanomedicines with electromagnetic energy for deep-tissue induction of immunogenic cell death in cancer immunotherapy
title_full_unstemmed Activating nanomedicines with electromagnetic energy for deep-tissue induction of immunogenic cell death in cancer immunotherapy
title_sort activating nanomedicines with electromagnetic energy for deep-tissue induction of immunogenic cell death in cancer immunotherapy
publishDate 2023
url https://hdl.handle.net/10356/164393
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