Toward precision phenotyping of multiple sclerosis

The classification of multiple sclerosis (MS) has been established by Lublin in 1996 and revised in 2013. The revision includes clinically isolated syndrome, relapsing-remitting, primary progressive and secondary progressive MS, and has added activity (i.e., formation of white matter lesions or clin...

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Main Authors: Pitt, David, Lo, Chih Hung, Gauthier, Susan A., Hickman, Richard A., Longbrake, Erin, Airas, Laura M., Mao-Draayer, Yang, Riley, Claire, De Jager, Philip Lawrence, Wesley, Sarah, Boster, Aaron, Topalli, Ilir, Bagnato, Francesca, Mansoor, Mohammad, Stuve, Olaf, Kister, Ilya, Pelletier, Daniel, Stathopoulos, Panos, Dutta, Ranjan, Lincoln, Matthew R.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2023
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Online Access:https://hdl.handle.net/10356/164428
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-1644282023-03-05T16:54:09Z Toward precision phenotyping of multiple sclerosis Pitt, David Lo, Chih Hung Gauthier, Susan A. Hickman, Richard A. Longbrake, Erin Airas, Laura M. Mao-Draayer, Yang Riley, Claire De Jager, Philip Lawrence Wesley, Sarah Boster, Aaron Topalli, Ilir Bagnato, Francesca Mansoor, Mohammad Stuve, Olaf Kister, Ilya Pelletier, Daniel Stathopoulos, Panos Dutta, Ranjan Lincoln, Matthew R. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Multiple Sclerosis Neurologic Disease The classification of multiple sclerosis (MS) has been established by Lublin in 1996 and revised in 2013. The revision includes clinically isolated syndrome, relapsing-remitting, primary progressive and secondary progressive MS, and has added activity (i.e., formation of white matter lesions or clinical relapses) as a qualifier. This allows for the distinction between active and nonactive progression, which has been shown to be of clinical importance. We propose that a logical extension of this classification is the incorporation of additional key pathological processes, such as chronic perilesional inflammation, neuroaxonal degeneration, and remyelination. This will distinguish MS phenotypes that may present as clinically identical but are driven by different combinations of pathological processes. A more precise description of MS phenotypes will improve prognostication and personalized care as well as clinical trial design. Thus, our proposal provides an expanded framework for conceptualizing MS and for guiding development of biomarkers for monitoring activity along the main pathological axes in MS. Published version Study Funding: Supported in part by NIH grants R01 NS102267 and R01 NS112907 (D.P.) and a career transition fellowship from the Consortium of Multiple Sclerosis Centers and the National Multiple Sclerosis Society (M.R.L.). The Article Processing Charge was funded by the authors. 2023-01-25T01:06:41Z 2023-01-25T01:06:41Z 2022 Journal Article Pitt, D., Lo, C. H., Gauthier, S. A., Hickman, R. A., Longbrake, E., Airas, L. M., Mao-Draayer, Y., Riley, C., De Jager, P. L., Wesley, S., Boster, A., Topalli, I., Bagnato, F., Mansoor, M., Stuve, O., Kister, I., Pelletier, D., Stathopoulos, P., Dutta, R. & Lincoln, M. R. (2022). Toward precision phenotyping of multiple sclerosis. Neurology® Neuroimmunology & Neuroinflammation, 9(6), e200025-. https://dx.doi.org/10.1212/NXI.0000000000200025 2332-7812 https://hdl.handle.net/10356/164428 10.1212/NXI.0000000000200025 36041861 2-s2.0-85136992193 6 9 e200025 en Neurology® Neuroimmunology & Neuroinflammation © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
Multiple Sclerosis
Neurologic Disease
spellingShingle Science::Medicine
Multiple Sclerosis
Neurologic Disease
Pitt, David
Lo, Chih Hung
Gauthier, Susan A.
Hickman, Richard A.
Longbrake, Erin
Airas, Laura M.
Mao-Draayer, Yang
Riley, Claire
De Jager, Philip Lawrence
Wesley, Sarah
Boster, Aaron
Topalli, Ilir
Bagnato, Francesca
Mansoor, Mohammad
Stuve, Olaf
Kister, Ilya
Pelletier, Daniel
Stathopoulos, Panos
Dutta, Ranjan
Lincoln, Matthew R.
Toward precision phenotyping of multiple sclerosis
description The classification of multiple sclerosis (MS) has been established by Lublin in 1996 and revised in 2013. The revision includes clinically isolated syndrome, relapsing-remitting, primary progressive and secondary progressive MS, and has added activity (i.e., formation of white matter lesions or clinical relapses) as a qualifier. This allows for the distinction between active and nonactive progression, which has been shown to be of clinical importance. We propose that a logical extension of this classification is the incorporation of additional key pathological processes, such as chronic perilesional inflammation, neuroaxonal degeneration, and remyelination. This will distinguish MS phenotypes that may present as clinically identical but are driven by different combinations of pathological processes. A more precise description of MS phenotypes will improve prognostication and personalized care as well as clinical trial design. Thus, our proposal provides an expanded framework for conceptualizing MS and for guiding development of biomarkers for monitoring activity along the main pathological axes in MS.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Pitt, David
Lo, Chih Hung
Gauthier, Susan A.
Hickman, Richard A.
Longbrake, Erin
Airas, Laura M.
Mao-Draayer, Yang
Riley, Claire
De Jager, Philip Lawrence
Wesley, Sarah
Boster, Aaron
Topalli, Ilir
Bagnato, Francesca
Mansoor, Mohammad
Stuve, Olaf
Kister, Ilya
Pelletier, Daniel
Stathopoulos, Panos
Dutta, Ranjan
Lincoln, Matthew R.
format Article
author Pitt, David
Lo, Chih Hung
Gauthier, Susan A.
Hickman, Richard A.
Longbrake, Erin
Airas, Laura M.
Mao-Draayer, Yang
Riley, Claire
De Jager, Philip Lawrence
Wesley, Sarah
Boster, Aaron
Topalli, Ilir
Bagnato, Francesca
Mansoor, Mohammad
Stuve, Olaf
Kister, Ilya
Pelletier, Daniel
Stathopoulos, Panos
Dutta, Ranjan
Lincoln, Matthew R.
author_sort Pitt, David
title Toward precision phenotyping of multiple sclerosis
title_short Toward precision phenotyping of multiple sclerosis
title_full Toward precision phenotyping of multiple sclerosis
title_fullStr Toward precision phenotyping of multiple sclerosis
title_full_unstemmed Toward precision phenotyping of multiple sclerosis
title_sort toward precision phenotyping of multiple sclerosis
publishDate 2023
url https://hdl.handle.net/10356/164428
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