Sustained activation of non-canonical NF-κB signalling drives glycolytic reprogramming in doxorubicin-resistant DLBCL

• Main Authors: Lim, Shen Kiat, Peng, Chen Chen, Low, Shannon, Vijay, Varsheni, Budiman, Andrea, Phang, Beng Hooi, Lim, Jing Quan, Jeyasekharan, Anand D., Lim, Soon Thye, Ong, Choon Kiat, Tan, Suet Mien, Li, Yinghui
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Cell Signalling; Non-Hodgkin Lymphoma
• Online Access: https://hdl.handle.net/10356/164468
• Institution: Nanyang Technological University

DLBCL is the most common lymphoma with high tumor heterogeneity. Treatment refractoriness and relapse from R-CHOP therapy in patients remain a clinical problem. Activation of the non-canonical NF-κB pathway is associated with R-CHOP resistance. However, downstream targets of non-canonical NF-κB medi...