Genetic admixture history and forensic characteristics of Tibeto-Burman-speaking Qiang people explored via the newly developed Y-STR panel and genome-wide SNP data

Fine-scale patterns of population genetic structure and diversity of ethnolinguistically diverse populations are important for biogeographical ancestry inference, kinship testing, and development and validation of new kits focused on forensic personal identification. Analyses focused on forensic mar...

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Main Authors: He, Guanglin, Adnan, Atif, Al-Qahtani, Wedad Saeed, Safhi, Fatmah Ahmed, Yeh, Hui-Yuan, Hadi, Sibte, Wang, Chuan-Chao, Wang, Mengge, Yao, Jun
Other Authors: School of Humanities
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Language:English
Published: 2023
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Online Access:https://hdl.handle.net/10356/164516
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spelling sg-ntu-dr.10356-1645162023-03-11T20:05:56Z Genetic admixture history and forensic characteristics of Tibeto-Burman-speaking Qiang people explored via the newly developed Y-STR panel and genome-wide SNP data He, Guanglin Adnan, Atif Al-Qahtani, Wedad Saeed Safhi, Fatmah Ahmed Yeh, Hui-Yuan Hadi, Sibte Wang, Chuan-Chao Wang, Mengge Wang, Mengge Yao, Jun School of Humanities Science::Biological sciences::Genetics Humanities::History Validation Forensic Genetics Fine-scale patterns of population genetic structure and diversity of ethnolinguistically diverse populations are important for biogeographical ancestry inference, kinship testing, and development and validation of new kits focused on forensic personal identification. Analyses focused on forensic markers and genome-wide single nucleotide polymorphism (SNP) data can provide new insights into the origin, admixture processes, and forensic characteristics of targeted populations. Qiang people had a large sample size among Tibeto-Burmanspeaking populations, which widely resided in the middle latitude of the Tibetan Plateau. However, their genetic structure and forensic features have remained uncharacterized because of the paucity of comprehensive genetic analyses. Here, we first developed and validated the forensic performance of the AGCU-Y30 Y-short tandem repeats (STR) panel, which contains slowly and moderately mutating Y-STRs, and then we conducted comprehensive population genetic analyses based on Y-STRs and genome-wide SNPs to explore the admixture history of Qiang people and their neighbors. The validated results of this panel showed that the new Y-STR kit was sensitive and robust enough for forensic applications. Haplotype diversity (HD) ranging from 0.9932 to 0.9996 and allelic frequencies ranging from 0.001946 to 0.8326 in 514 Qiang people demonstrated that all included markers were highly polymorphic in Tibeto-Burman people. Population genetic analyses based on Y-STRs [RST, FST, multidimensional scaling (MDS) analysis, neighboring-joining (NJ) tree, principal component analysis (PCA), and median-joining network (MJN)] revealed that the Qiang people harbored a paternally close relationship with lowland Tibetan-Yi corridor populations. Furthermore, we conducted a comprehensive population admixture analysis among modern and ancient Eurasian populations based on genome-wide shared SNPs. We found that the Qiang people were a genetically admixed population and showed closest relationship with Tibetan and Neolithic Yellow River farmers. Admixture modeling showed that Qiang people shared the primary ancestry related to Tibetan, supporting the hypothesis of common origin between Tibetan and Qiang people from North China. Published version This research was Funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2022R318) and Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. 2023-01-30T06:26:32Z 2023-01-30T06:26:32Z 2022 Journal Article He, G., Adnan, A., Al-Qahtani, W. S., Safhi, F. A., Yeh, H., Hadi, S., Wang, C., Wang, M., Wang, M. & Yao, J. (2022). Genetic admixture history and forensic characteristics of Tibeto-Burman-speaking Qiang people explored via the newly developed Y-STR panel and genome-wide SNP data. Frontiers in Ecology and Evolution, 10, 939659-. https://dx.doi.org/10.3389/fevo.2022.939659 2296-701X https://hdl.handle.net/10356/164516 10.3389/fevo.2022.939659 2-s2.0-85141729001 10 939659 en Frontiers in Ecology and Evolution © 2022 He, Adnan, Al-Qahtani, Safhi, Yeh, Hadi, Wang, Wang, Liu and Yao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Biological sciences::Genetics
Humanities::History
Validation
Forensic Genetics
spellingShingle Science::Biological sciences::Genetics
Humanities::History
Validation
Forensic Genetics
He, Guanglin
Adnan, Atif
Al-Qahtani, Wedad Saeed
Safhi, Fatmah Ahmed
Yeh, Hui-Yuan
Hadi, Sibte
Wang, Chuan-Chao
Wang, Mengge
Wang, Mengge
Yao, Jun
Genetic admixture history and forensic characteristics of Tibeto-Burman-speaking Qiang people explored via the newly developed Y-STR panel and genome-wide SNP data
description Fine-scale patterns of population genetic structure and diversity of ethnolinguistically diverse populations are important for biogeographical ancestry inference, kinship testing, and development and validation of new kits focused on forensic personal identification. Analyses focused on forensic markers and genome-wide single nucleotide polymorphism (SNP) data can provide new insights into the origin, admixture processes, and forensic characteristics of targeted populations. Qiang people had a large sample size among Tibeto-Burmanspeaking populations, which widely resided in the middle latitude of the Tibetan Plateau. However, their genetic structure and forensic features have remained uncharacterized because of the paucity of comprehensive genetic analyses. Here, we first developed and validated the forensic performance of the AGCU-Y30 Y-short tandem repeats (STR) panel, which contains slowly and moderately mutating Y-STRs, and then we conducted comprehensive population genetic analyses based on Y-STRs and genome-wide SNPs to explore the admixture history of Qiang people and their neighbors. The validated results of this panel showed that the new Y-STR kit was sensitive and robust enough for forensic applications. Haplotype diversity (HD) ranging from 0.9932 to 0.9996 and allelic frequencies ranging from 0.001946 to 0.8326 in 514 Qiang people demonstrated that all included markers were highly polymorphic in Tibeto-Burman people. Population genetic analyses based on Y-STRs [RST, FST, multidimensional scaling (MDS) analysis, neighboring-joining (NJ) tree, principal component analysis (PCA), and median-joining network (MJN)] revealed that the Qiang people harbored a paternally close relationship with lowland Tibetan-Yi corridor populations. Furthermore, we conducted a comprehensive population admixture analysis among modern and ancient Eurasian populations based on genome-wide shared SNPs. We found that the Qiang people were a genetically admixed population and showed closest relationship with Tibetan and Neolithic Yellow River farmers. Admixture modeling showed that Qiang people shared the primary ancestry related to Tibetan, supporting the hypothesis of common origin between Tibetan and Qiang people from North China.
author2 School of Humanities
author_facet School of Humanities
He, Guanglin
Adnan, Atif
Al-Qahtani, Wedad Saeed
Safhi, Fatmah Ahmed
Yeh, Hui-Yuan
Hadi, Sibte
Wang, Chuan-Chao
Wang, Mengge
Wang, Mengge
Yao, Jun
format Article
author He, Guanglin
Adnan, Atif
Al-Qahtani, Wedad Saeed
Safhi, Fatmah Ahmed
Yeh, Hui-Yuan
Hadi, Sibte
Wang, Chuan-Chao
Wang, Mengge
Wang, Mengge
Yao, Jun
author_sort He, Guanglin
title Genetic admixture history and forensic characteristics of Tibeto-Burman-speaking Qiang people explored via the newly developed Y-STR panel and genome-wide SNP data
title_short Genetic admixture history and forensic characteristics of Tibeto-Burman-speaking Qiang people explored via the newly developed Y-STR panel and genome-wide SNP data
title_full Genetic admixture history and forensic characteristics of Tibeto-Burman-speaking Qiang people explored via the newly developed Y-STR panel and genome-wide SNP data
title_fullStr Genetic admixture history and forensic characteristics of Tibeto-Burman-speaking Qiang people explored via the newly developed Y-STR panel and genome-wide SNP data
title_full_unstemmed Genetic admixture history and forensic characteristics of Tibeto-Burman-speaking Qiang people explored via the newly developed Y-STR panel and genome-wide SNP data
title_sort genetic admixture history and forensic characteristics of tibeto-burman-speaking qiang people explored via the newly developed y-str panel and genome-wide snp data
publishDate 2023
url https://hdl.handle.net/10356/164516
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