Identification of biomarker in patients on high dose warfarin : an iTRAQ-coupled LC-MS/MS approach

• Main Author: Lee, Joanne Hui Yi.
• Other Authors: Chen Wei Ning, William
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Engineering::Chemical engineering::Biotechnology
• Online Access: http://hdl.handle.net/10356/16452
• Institution: Nanyang Technological University

Warfarin is a widely prescribed anticoagulant for the treatment and prevention of thrombotic diseases. Warfarin has a narrow therapeutic range and a given dose has more than 10-fold inter-individual variability in its pharmacodynamic effects. An insufficient dose may fail to prevent thromboembolism...