The role of tyrosine hydroxylase-dopamine pathway in Parkinson's disease pathogenesis

• Main Authors: Zhou, Zhi Dong, Saw, Wuan Ting, Ho, Patrick Ghim Hoe, Zhang, Zhi Wei, Zeng, Li, Chang, Ya Yin, Sun, Alfred Xu Yang, Ma, Dong Rui, Wang, Hong Yan, Zhou, Lei, Lim, Kah-Leong, Tan, Eng-King
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Dopamine; Neurodegeneration
• Online Access: https://hdl.handle.net/10356/164554
• Institution: Nanyang Technological University

Background: Parkinson’s disease (PD) is characterized by selective and progressive dopamine (DA) neuron loss in the substantia nigra and other brain regions, with the presence of Lewy body formation. Most PD cases are sporadic, whereas monogenic forms of PD have been linked to multiple genes, includ...