Evaluating primary endpoints for COVID-19 therapeutic trials to assess recovery

• Main Authors: Douin, David J., Siegel, Lianne, Grandits, Greg, Phillips, Andrew, Aggarwal, Neil R., Baker, Jason, Brown, Samuel M., Chang, Christina C., Goodman, Anna L., Grund, Birgit, Higgs, Elizabeth S., Hough, Catherine L., Murray, Daniel D., Paredes, Roger, Parmar, Mahesh, Pett, Sarah, Polizzotto, Mark N., Sandkovsky, Uriel, Self, Wesley H., Young, Barnaby Edward, Babiker, Abdel G., Davey, Victoria J., Kan, Virginia, Gelijns, Annetine C., Matthews, Gail, Thompson, B. Taylor, Lane, H. Clifford, Neaton, James D., Lundgren, Jens D., Ginde, Adit A.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; COVID-19; Outcomes Assessment
• Online Access: https://hdl.handle.net/10356/164556
• Institution: Nanyang Technological University

Rationale: Uncertainty regarding the natural history of coronavirus disease (COVID-19) led to difficulty in efficacy endpoint selection for therapeutic trials. Capturing outcomes that occur after hospital discharge may improve assessment of clinical recovery among hospitalized patients with COVID-19...