DNA methylation levels of RELN promoter region in ultra-high risk, first episode and chronic schizophrenia cohorts of schizophrenia

• Main Authors: Kho, Sok-Hong, Yee, Jie Yin, Puang, Shu Juan, Han, Luke, Chiang, Christine, Rapisarda, Attilio, Goh, Wilson Wen Bin, Lee, Jimmy, Sng, Judy Chia Ghee
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Bisulfite Pyrosequencing; Cohort Analysis
• Online Access: https://hdl.handle.net/10356/164581
• Institution: Nanyang Technological University

The essential role of the Reelin gene (RELN) during brain development makes it a prominent candidate in human epigenetic studies of Schizophrenia. Previous literature has reported differing levels of DNA methylation (DNAm) in patients with psychosis. Therefore, this study aimed to (1) examine and co...