Resonant enhancement of polymer-cell optostimulation by a plasmonic metasurface

Organic semiconductors have shown great potential as efficient bioelectronic materials. Specifically, photovoltaic polymers such as the workhorse poly(thiophene) derivatives, when stimulated with visible light, can depolarize neurons and generate action potentials, an effect that has been also emplo...

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Main Authors: Maity, Arijit, Perotto, Sara, Moschetta, Matteo, Hua, Huang, Sardar, Samim, Paternò, Giuseppe Maria, Tian, Jingyi, Klein, Maciej, Adamo, Giorgio, Lanzani, Guglielmo, Soci, Cesare
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2023
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Online Access:https://hdl.handle.net/10356/164636
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1646362023-02-28T20:11:51Z Resonant enhancement of polymer-cell optostimulation by a plasmonic metasurface Maity, Arijit Perotto, Sara Moschetta, Matteo Hua, Huang Sardar, Samim Paternò, Giuseppe Maria Tian, Jingyi Klein, Maciej Adamo, Giorgio Lanzani, Guglielmo Soci, Cesare School of Physical and Mathematical Sciences The Photonics Institute Centre for Disruptive Photonic Technologies (CDPT) Science::Physics Organic Semiconductors Plasmonic Metasurface Organic semiconductors have shown great potential as efficient bioelectronic materials. Specifically, photovoltaic polymers such as the workhorse poly(thiophene) derivatives, when stimulated with visible light, can depolarize neurons and generate action potentials, an effect that has been also employed for rescuing vision in blind rats. In this context, however, the coupling of such materials with optically resonant structures to enhance those photodriven biological effects is still in its infancy. Here, we employ the optical coupling between a nanostructured metasurface and poly(3-hexylthiophene) (P3HT) to improve the bioelectronic effects occurring upon photostimulation at the abiotic-biotic interface. In particular, we designed a spectrally tuned aluminum metasurface that can resonate with P3HT, hence augmenting the effective field experienced by the polymer. In turn, this leads to an 8-fold increase in invoked inward current in cells. This enhanced activation strategy could be useful to increase the effectiveness of P3HT-based prosthetic implants for degenerative retinal disorders. Ministry of Education (MOE) Published version This work was supported by the Singapore Ministry of Education Academic Research Fund Tier 1 (2018-T1-002- 040). 2023-02-07T02:24:23Z 2023-02-07T02:24:23Z 2022 Journal Article Maity, A., Perotto, S., Moschetta, M., Hua, H., Sardar, S., Paternò, G. M., Tian, J., Klein, M., Adamo, G., Lanzani, G. & Soci, C. (2022). Resonant enhancement of polymer-cell optostimulation by a plasmonic metasurface. ACS Omega, 7(47), 42674-42680. https://dx.doi.org/10.1021/acsomega.2c04812 2470-1343 https://hdl.handle.net/10356/164636 10.1021/acsomega.2c04812 36467911 2-s2.0-85142606846 47 7 42674 42680 en 2018-T1-002- 040 ACS Omega © 2022 The Authors. Published by American Chemical Society. This is an open-access article distributed under the terms of the Creative Commons Attribution License. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Physics
Organic Semiconductors
Plasmonic Metasurface
spellingShingle Science::Physics
Organic Semiconductors
Plasmonic Metasurface
Maity, Arijit
Perotto, Sara
Moschetta, Matteo
Hua, Huang
Sardar, Samim
Paternò, Giuseppe Maria
Tian, Jingyi
Klein, Maciej
Adamo, Giorgio
Lanzani, Guglielmo
Soci, Cesare
Resonant enhancement of polymer-cell optostimulation by a plasmonic metasurface
description Organic semiconductors have shown great potential as efficient bioelectronic materials. Specifically, photovoltaic polymers such as the workhorse poly(thiophene) derivatives, when stimulated with visible light, can depolarize neurons and generate action potentials, an effect that has been also employed for rescuing vision in blind rats. In this context, however, the coupling of such materials with optically resonant structures to enhance those photodriven biological effects is still in its infancy. Here, we employ the optical coupling between a nanostructured metasurface and poly(3-hexylthiophene) (P3HT) to improve the bioelectronic effects occurring upon photostimulation at the abiotic-biotic interface. In particular, we designed a spectrally tuned aluminum metasurface that can resonate with P3HT, hence augmenting the effective field experienced by the polymer. In turn, this leads to an 8-fold increase in invoked inward current in cells. This enhanced activation strategy could be useful to increase the effectiveness of P3HT-based prosthetic implants for degenerative retinal disorders.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Maity, Arijit
Perotto, Sara
Moschetta, Matteo
Hua, Huang
Sardar, Samim
Paternò, Giuseppe Maria
Tian, Jingyi
Klein, Maciej
Adamo, Giorgio
Lanzani, Guglielmo
Soci, Cesare
format Article
author Maity, Arijit
Perotto, Sara
Moschetta, Matteo
Hua, Huang
Sardar, Samim
Paternò, Giuseppe Maria
Tian, Jingyi
Klein, Maciej
Adamo, Giorgio
Lanzani, Guglielmo
Soci, Cesare
author_sort Maity, Arijit
title Resonant enhancement of polymer-cell optostimulation by a plasmonic metasurface
title_short Resonant enhancement of polymer-cell optostimulation by a plasmonic metasurface
title_full Resonant enhancement of polymer-cell optostimulation by a plasmonic metasurface
title_fullStr Resonant enhancement of polymer-cell optostimulation by a plasmonic metasurface
title_full_unstemmed Resonant enhancement of polymer-cell optostimulation by a plasmonic metasurface
title_sort resonant enhancement of polymer-cell optostimulation by a plasmonic metasurface
publishDate 2023
url https://hdl.handle.net/10356/164636
_version_ 1759855734619635712