Squid suckerin-spider silk fusion protein hydrogel for delivery of mesenchymal stem cell secretome to chronic wounds

• Main Authors: Koh, Kenrick, Wang, Jun Kit, Chen, James Xiao Yuan, Hiew, Shu Hui, Cheng, Hong Sheng, Gabryelczyk, Bartosz, Vos, Marcus Ivan Gerard, Yip, Yun Sheng, Chen, Liyan, Sobota, Radoslaw M., Chua, Damian Kang Keat, Tan, Nguan Soon, Tay, Chor Yong, Miserez, Ali
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Materials; Chronic Wound Healing; Drug Delivery
• Online Access: https://hdl.handle.net/10356/164644
• Institution: Nanyang Technological University

Chronic wounds are non-healing wounds characterized by a prolonged inflammation phase. Excessive inflammation leads to elevated protease levels and consequently to a decrease in growth factors at wound sites. Stem cell secretome therapy has been identified as a treatment strategy to modulate the mic...