A review of membrane fouling by proteins in ultrafiltration and microfiltration

Fouling of ultrafiltration (UF) and microfiltration (MF) membranes by proteins is a major challenge in the bioprocessing and dairy industries, as well as in surface and wastewater treatment applications. This review attempts at presenting a comprehensive state-of-the-art understanding on protein fou...

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Main Authors: Tanudjaja, Henry Jonathan, Anantharaman, Aditya, Ng, Angie Qi Qi, Ma, Yunqiao, Tanis-Kanbur, Melike Begüm, Zydney, Andrew L., Chew, Jia Wei
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2023
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Online Access:https://hdl.handle.net/10356/164680
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1646802023-02-08T07:49:19Z A review of membrane fouling by proteins in ultrafiltration and microfiltration Tanudjaja, Henry Jonathan Anantharaman, Aditya Ng, Angie Qi Qi Ma, Yunqiao Tanis-Kanbur, Melike Begüm Zydney, Andrew L. Chew, Jia Wei School of Chemical and Biomedical Engineering Interdisciplinary Graduate School (IGS) Singapore Membrane Technology Centre Nanyang Environment and Water Research Institute Engineering::Civil engineering Protein Fouling Ultrafiltration and Microfiltration Fouling of ultrafiltration (UF) and microfiltration (MF) membranes by proteins is a major challenge in the bioprocessing and dairy industries, as well as in surface and wastewater treatment applications. This review attempts at presenting a comprehensive state-of-the-art understanding on protein fouling of membranes. Effects of operating conditions, along with properties of proteins and membranes, are discussed. Various tools and techniques used to characterize and monitor fouling are described. Different mitigation techniques and cleaning methods used are also presented. Two main factors have been identified as playing important roles in governing protein fouling, namely, ratio of protein size to membrane pore size and interfacial interactions (i.e., protein-protein and protein-membrane). Some directions for future research are suggested: (1) explore a wider range of proteins and their mixtures with respect to their fouling tendencies; and (2) create a comprehensive dataset that can be used to develop machine-learning models to enhance both predictive capabilities and mechanistic understanding. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) This study was supported by A*STAR (Singapore) Advanced Manufacturing and Engineering (AME) under its Pharma Innovation Programme Singapore (PIPS) (A20B3a0070); A*STAR (Singapore) Advanced Manufacturing and Engineering (AME) under its Individual Research Grant (IRG) program (A2083c0049); the Singapore Ministry of Education Academic Research Tier 1 Grant (2019-T1-002-065; RG100/ 19) and the Singapore Ministry of Education Academic Research Tier 2 Grant (MOE-MOET2EP10120-0001). 2023-02-08T07:49:19Z 2023-02-08T07:49:19Z 2022 Journal Article Tanudjaja, H. J., Anantharaman, A., Ng, A. Q. Q., Ma, Y., Tanis-Kanbur, M. B., Zydney, A. L. & Chew, J. W. (2022). A review of membrane fouling by proteins in ultrafiltration and microfiltration. Journal of Water Process Engineering, 50, 103294-. https://dx.doi.org/10.1016/j.jwpe.2022.103294 2214-7144 https://hdl.handle.net/10356/164680 10.1016/j.jwpe.2022.103294 2-s2.0-85141765508 50 103294 en A20B3a0070 A2083c0049 2019-T1-002-065 RG100/19 MOE-MOET2EP10120-0001 Journal of Water Process Engineering © 2022 Elsevier Ltd. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Civil engineering
Protein Fouling
Ultrafiltration and Microfiltration
spellingShingle Engineering::Civil engineering
Protein Fouling
Ultrafiltration and Microfiltration
Tanudjaja, Henry Jonathan
Anantharaman, Aditya
Ng, Angie Qi Qi
Ma, Yunqiao
Tanis-Kanbur, Melike Begüm
Zydney, Andrew L.
Chew, Jia Wei
A review of membrane fouling by proteins in ultrafiltration and microfiltration
description Fouling of ultrafiltration (UF) and microfiltration (MF) membranes by proteins is a major challenge in the bioprocessing and dairy industries, as well as in surface and wastewater treatment applications. This review attempts at presenting a comprehensive state-of-the-art understanding on protein fouling of membranes. Effects of operating conditions, along with properties of proteins and membranes, are discussed. Various tools and techniques used to characterize and monitor fouling are described. Different mitigation techniques and cleaning methods used are also presented. Two main factors have been identified as playing important roles in governing protein fouling, namely, ratio of protein size to membrane pore size and interfacial interactions (i.e., protein-protein and protein-membrane). Some directions for future research are suggested: (1) explore a wider range of proteins and their mixtures with respect to their fouling tendencies; and (2) create a comprehensive dataset that can be used to develop machine-learning models to enhance both predictive capabilities and mechanistic understanding.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Tanudjaja, Henry Jonathan
Anantharaman, Aditya
Ng, Angie Qi Qi
Ma, Yunqiao
Tanis-Kanbur, Melike Begüm
Zydney, Andrew L.
Chew, Jia Wei
format Article
author Tanudjaja, Henry Jonathan
Anantharaman, Aditya
Ng, Angie Qi Qi
Ma, Yunqiao
Tanis-Kanbur, Melike Begüm
Zydney, Andrew L.
Chew, Jia Wei
author_sort Tanudjaja, Henry Jonathan
title A review of membrane fouling by proteins in ultrafiltration and microfiltration
title_short A review of membrane fouling by proteins in ultrafiltration and microfiltration
title_full A review of membrane fouling by proteins in ultrafiltration and microfiltration
title_fullStr A review of membrane fouling by proteins in ultrafiltration and microfiltration
title_full_unstemmed A review of membrane fouling by proteins in ultrafiltration and microfiltration
title_sort review of membrane fouling by proteins in ultrafiltration and microfiltration
publishDate 2023
url https://hdl.handle.net/10356/164680
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