Gut-skin axis: unravelling the connection between the gut microbiome and psoriasis
Evidence has shown that gut microbiome plays a role in modulating the development of diseases beyond the gastrointestinal tract, including skin disorders such as psoriasis. The gut-skin axis refers to the bidirectional relationship between the gut microbiome and skin health. This is regulated throug...
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sg-ntu-dr.10356-1648082023-03-05T16:55:08Z Gut-skin axis: unravelling the connection between the gut microbiome and psoriasis Thye, Angel Yun-Kuan Bah, Yi-Rou Law, Jodi Woan-Fei Tan, Loh Teng-Hern He, Ya-Wen Wong, Sunny Hei Thurairajasingam, Sivakumar Chan, Kok-Gan Lee, Learn-Han Letchumanan, Vengadesh Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Microbiota Skin Disease Evidence has shown that gut microbiome plays a role in modulating the development of diseases beyond the gastrointestinal tract, including skin disorders such as psoriasis. The gut-skin axis refers to the bidirectional relationship between the gut microbiome and skin health. This is regulated through several mechanisms such as inflammatory mediators and the immune system. Dysregulation of microbiota has been seen in numerous inflammatory skin conditions such as atopic dermatitis, rosacea, and psoriasis. Understanding how gut microbiome are involved in regulating skin health may lead to development of novel therapies for these skin disorders through microbiome modulation, in particularly psoriasis. In this review, we will compare the microbiota between psoriasis patients and healthy control, explain the concept of gut-skin axis and the effects of gut dysbiosis on skin physiology. We will also review the current evidence on modulating gut microbiome using probiotics in psoriasis. Published version This work is supported by the Jeffrey Cheah School of Medicine and Health Sciences Strategic Grant 2021 (Vote Number: STG-000051), External Industry Grant from Biomerge Sdn Bhd (Vote no. BMRG2018-01) awarded to L.-H.L., and University of Malaya Research Grant (FRGS Grant no: FP022-2018A) awarded to K.-G.C. 2023-02-15T03:25:25Z 2023-02-15T03:25:25Z 2022 Journal Article Thye, A. Y., Bah, Y., Law, J. W., Tan, L. T., He, Y., Wong, S. H., Thurairajasingam, S., Chan, K., Lee, L. & Letchumanan, V. (2022). Gut-skin axis: unravelling the connection between the gut microbiome and psoriasis. Biomedicines, 10(5), 10051037-. https://dx.doi.org/10.3390/biomedicines10051037 2227-9059 https://hdl.handle.net/10356/164808 10.3390/biomedicines10051037 35625774 2-s2.0-85129952715 5 10 10051037 en Biomedicines © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). application/pdf |
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Science::Medicine Microbiota Skin Disease Thye, Angel Yun-Kuan Bah, Yi-Rou Law, Jodi Woan-Fei Tan, Loh Teng-Hern He, Ya-Wen Wong, Sunny Hei Thurairajasingam, Sivakumar Chan, Kok-Gan Lee, Learn-Han Letchumanan, Vengadesh Gut-skin axis: unravelling the connection between the gut microbiome and psoriasis |
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Evidence has shown that gut microbiome plays a role in modulating the development of diseases beyond the gastrointestinal tract, including skin disorders such as psoriasis. The gut-skin axis refers to the bidirectional relationship between the gut microbiome and skin health. This is regulated through several mechanisms such as inflammatory mediators and the immune system. Dysregulation of microbiota has been seen in numerous inflammatory skin conditions such as atopic dermatitis, rosacea, and psoriasis. Understanding how gut microbiome are involved in regulating skin health may lead to development of novel therapies for these skin disorders through microbiome modulation, in particularly psoriasis. In this review, we will compare the microbiota between psoriasis patients and healthy control, explain the concept of gut-skin axis and the effects of gut dysbiosis on skin physiology. We will also review the current evidence on modulating gut microbiome using probiotics in psoriasis. |
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Lee Kong Chian School of Medicine (LKCMedicine) |
author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Thye, Angel Yun-Kuan Bah, Yi-Rou Law, Jodi Woan-Fei Tan, Loh Teng-Hern He, Ya-Wen Wong, Sunny Hei Thurairajasingam, Sivakumar Chan, Kok-Gan Lee, Learn-Han Letchumanan, Vengadesh |
format |
Article |
author |
Thye, Angel Yun-Kuan Bah, Yi-Rou Law, Jodi Woan-Fei Tan, Loh Teng-Hern He, Ya-Wen Wong, Sunny Hei Thurairajasingam, Sivakumar Chan, Kok-Gan Lee, Learn-Han Letchumanan, Vengadesh |
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Thye, Angel Yun-Kuan |
title |
Gut-skin axis: unravelling the connection between the gut microbiome and psoriasis |
title_short |
Gut-skin axis: unravelling the connection between the gut microbiome and psoriasis |
title_full |
Gut-skin axis: unravelling the connection between the gut microbiome and psoriasis |
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Gut-skin axis: unravelling the connection between the gut microbiome and psoriasis |
title_full_unstemmed |
Gut-skin axis: unravelling the connection between the gut microbiome and psoriasis |
title_sort |
gut-skin axis: unravelling the connection between the gut microbiome and psoriasis |
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2023 |
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https://hdl.handle.net/10356/164808 |
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