MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration

• Main Authors: Ren, Mengda, Yang, Ying, Heng, Kelsey Hwee Yee, Ng, Lu Yi, Chong, Claris Yuin-Yi, Ng, Yan Ting, Gorur-Shandilya, Srinivas, Lee, Rachel Min Qi, Lim, Kah Leong, Zhang, Jing, Koh, Tong-Wey
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Genetic Modifiers; Parkinson's Disease
• Online Access: https://hdl.handle.net/10356/164883
• Institution: Nanyang Technological University

α-Synuclein (α-syn) is important in synucleinopathies such as Parkinson's disease (PD). While genome-wide association studies (GWASs) of synucleinopathies have identified many risk loci, the underlying genes have not been shown for most loci. Using Drosophila, we screened 3,471 mutant chromosom...