Enhanced long-term potentiation and impaired learning in mice lacking alternative exon 33 of Caᵥ1.2 calcium channel

• Main Authors: Navakkode, Sheeja, Zhai, Jing, Wong, Yuk Peng, Li, Guang, Soong, Tuck Wah
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Long Term Potentiation; Learning Disorder
• Online Access: https://hdl.handle.net/10356/165036
• Institution: Nanyang Technological University

The CACNA1C (calcium voltage-gated channel subunit alpha 1 C) gene that encodes the CaV1.2 channel is a prominent risk gene for neuropsychiatric and neurodegenerative disorders with cognitive and social impairments like schizophrenia, bipolar disorders, depression and autistic spectrum disorders (AS...