Isolation and propagation of human corneal stromal keratocytes for tissue engineering and cell therapy

• Main Authors: Nur Zahirah Binte M. Yusoff, Riau, Andri K., Yam, Gary H. F., Nuur Shahinda Humaira Binte Halim, Mehta, Jodhbir Singh
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Materials; Science::Medicine; Keratocytes; Corneal Stroma
• Online Access: https://hdl.handle.net/10356/165250
• Institution: Nanyang Technological University

The human corneal stroma contains corneal stromal keratocytes (CSKs) that synthesize and deposit collagens and keratan sulfate proteoglycans into the stromal matrix to maintain the corneal structural integrity and transparency. In adult corneas, CSKs are quiescent and arrested in the G0 phase of the...