Ultra-short cyclized β-boomerang peptides: structures, interactions with lipopolysaccharide, antibiotic potentiator and wound healing

• Main Authors: Sinha, Sheetal, Dhanabal, Vidhya Bharathi, Manivannen, Veronica Lavanya, Cappiello, Floriana, Tan, Suet-Mien, Bhattacharjya, Surajit
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Antibiotic Potentiator; Cyclic Peptide
• Online Access: https://hdl.handle.net/10356/165612
• Institution: Nanyang Technological University

Many antibiotics are ineffective in killing Gram-negative bacteria due to the permeability barrier of the outer-membrane LPS. Infections caused by multi-drug-resistant Gram-negative pathogens require new antibiotics, which are often difficult to develop. Antibiotic potentiators disrupt outer-membran...