Modulating T-cell activation with antisense oligoucleotides targeting lymphocyte cytosolic protein 2

• Main Authors: Iyer, Vaishnavi Srinivasan, Boddul, Sanjaykumar V., Johnsson, Anna-Karin, Raposo, Bruno, Sharma, Ravi K., Shen, Yunbing, Kasza, Zsolt, Lim, Kah Wai, Chemin, Karine, Nilsson, Gunnar, Malmström, Vivianne, Phan, Anh Tuân, Wermeling, Fredrik
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Antisense Oligonucleotides; T-Cell Activation
• Online Access: https://hdl.handle.net/10356/165633
• Institution: Nanyang Technological University

Dysregulated T-cell activation is a hallmark of several autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS). The lymphocyte cytosolic protein 2 (LCP2), also known as SLP-76, is essential for the development and activation of T cells. Despite the critical role of LCP2 in...