Modelling of steady state recycle chromatographic process.

• Main Author: Poon, Kit Bun.
• Other Authors: Arvind Rajendran
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Science::Chemistry::Analytical chemistry::Chromatography
• Online Access: http://hdl.handle.net/10356/16566
• Institution: Nanyang Technological University

The aim of this work is to model steady state recycle chromatography. The areas of work in this project can be classified into two parts. In the first part, modelling of a chromatographic column using mass balance was carried out. Parametric studies of the chromatography process were conducted to gain in-depth understanding of the effect of the parameters on the performance of the chromatography process. Validation studies were also conducted on the basic model based on linear and Langmuir isotherms. The basic model was used to benchmark the enantioseparation of 1-phenyl-1-propanol before progression into the next phase of the project. In the second part of this project, the model was modified to simulate two methods of recycle chromatography, closed loop recycle and steady state recycle chromatography. Peak shavings were included to optimize the recycle chromatography processes. Key parameters monitored were productivity and solvent consumption. It is essential for these processes to be optimized for increased productivity and decreased solvent consumption, hence enhancing the process economics. The factors affecting the performance of closed loop recycle chromatography was conducted through varying injection concentration and injection width. For steady state recycle chromatography, factors affecting throughput, productivity and solvent consumption were examined. Introduction of the concept of time delay was employed in steady state recycle chromatography to prevent overlaps in the chromatogram of subsequent cycles.