Synthesis resolution of 3,4,3'4'-tetramethoxyl-1,1'-1,2,3,4-tetrahydrobisisoquinoline and application in asymmetric alkylation reactions

• Main Author: Almeida Hazel Virgilia Ann
• Other Authors: Zaher Judeh
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Engineering::Chemical engineering::Biochemical engineering
• Online Access: http://hdl.handle.net/10356/16572
• Institution: Nanyang Technological University

This report describes the synthesis of chiral 3,4,3',4'-tetramethoxyl-1,1'-1,2,3,4-tetrahydrobisisoquinoline. The compound is to be later used as a catalyst in the asymmetric alkylation addition reaction between 2-propargyl acetate and benzaldehyde to form an allylic alcohol. Racemic...