Atroposelective access to 1,3-oxazepine-containing bridged biaryls via carbene-catalyzed desymmetrization of imines

• المؤلفون الرئيسيون: Yang, Xing, Wei, Liwen, Wu, Yuelin, Zhou, Liejin, Zhang, Xinglong, Chi, Robin Yonggui
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Chemistry; Atropisomerism; Bridged Biaryls
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/166232
• المؤسسة: Nanyang Technological University

We disclose herein an atroposelective synthesis of novel bridged biaryls containing medium-sized rings via N-heterocyclic carbene organocatalysis. The reaction starts with addition of the carbene catalyst to the aminophenol-derived aldimine substrate. Subsequent oxidation and intramolecular desymmet...