Design, synthesis, and characterization of chiral porous material.
Recently, preparations of chiral silica materials have attracted significant attentions due to their potential application on chiral discrimination and drug delivery. In this study, the design, characterization and synthesis of novel enantioselective, large pore-diameter silica has been successfully...
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2009
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sg-ntu-dr.10356-166372023-03-03T15:38:42Z Design, synthesis, and characterization of chiral porous material. Quek, Lyn Wee Li. Yang Yanhui School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering::Biochemical engineering Recently, preparations of chiral silica materials have attracted significant attentions due to their potential application on chiral discrimination and drug delivery. In this study, the design, characterization and synthesis of novel enantioselective, large pore-diameter silica has been successfully reported. Specifically, chiral SBA-15 and SBA-16 were synthesized using achiral surfactant as template and a chiral dopant, Λ-[Co(+)(chxn)3]I3 to induce chirality in the silica source. The formation mechanism for the chiral silica is by means of surfactant-templated self assembly followed by the induction of chirality by the as-synthesized chiral cobalt complex. It is reported that both the extracted chiral silica appeared to be capable of chiral discrimination in virtue of the enantioselective controlled release of a chiral drug, metoprolol which is non-associated with the chiral co-template. In comparison, chiral mesoporous SBA-15 exhibits better stereoselectivity than chiral SBA-16 for the resolution of chiral metoprolol drug. In a nutshell, chiral SBA-15 with enantioselective characteristics could be a potential candidate for further applications in drug delivery, drug separation, chiral catalysis and chiral sensing. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2009-05-27T08:05:57Z 2009-05-27T08:05:57Z 2009 2009 Final Year Project (FYP) http://hdl.handle.net/10356/16637 en Nanyang Technological University 36 p. application/pdf |
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DRNTU::Engineering::Chemical engineering::Biochemical engineering Quek, Lyn Wee Li. Design, synthesis, and characterization of chiral porous material. |
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Recently, preparations of chiral silica materials have attracted significant attentions due to their potential application on chiral discrimination and drug delivery. In this study, the design, characterization and synthesis of novel enantioselective, large pore-diameter silica has been successfully reported. Specifically, chiral SBA-15 and SBA-16 were synthesized using achiral surfactant as template and a chiral dopant, Λ-[Co(+)(chxn)3]I3 to induce chirality in the silica source. The formation mechanism for the chiral silica is by means of surfactant-templated self assembly followed by the induction of chirality by the as-synthesized chiral cobalt complex. It is reported that both the extracted chiral silica appeared to be capable of chiral discrimination in virtue of the enantioselective controlled release of a chiral drug, metoprolol which is non-associated with the chiral co-template. In comparison, chiral mesoporous SBA-15 exhibits better stereoselectivity than chiral SBA-16 for the resolution of chiral metoprolol drug. In a nutshell, chiral SBA-15 with enantioselective characteristics could be a potential candidate for further applications in drug delivery, drug separation, chiral catalysis and chiral sensing. |
author2 |
Yang Yanhui |
author_facet |
Yang Yanhui Quek, Lyn Wee Li. |
format |
Final Year Project |
author |
Quek, Lyn Wee Li. |
author_sort |
Quek, Lyn Wee Li. |
title |
Design, synthesis, and characterization of chiral porous material. |
title_short |
Design, synthesis, and characterization of chiral porous material. |
title_full |
Design, synthesis, and characterization of chiral porous material. |
title_fullStr |
Design, synthesis, and characterization of chiral porous material. |
title_full_unstemmed |
Design, synthesis, and characterization of chiral porous material. |
title_sort |
design, synthesis, and characterization of chiral porous material. |
publishDate |
2009 |
url |
http://hdl.handle.net/10356/16637 |
_version_ |
1759856952811192320 |