Formulation of micron-scale carrier particles of nanoparticulate drug : effects of nanoparticle size, chemical nature and concentration.

Pulmonary delivery of the nanoparticles to the lungs serves as an attractive route due to the high solute permeability and large surface area for absorption. The nanoparticles are able to escape the phagocytic clearance mechanism in the lungs, but their small sizes often results in the particles bei...

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Main Author: Kok, Hui Hua.
Other Authors: Kunn Hadinoto Ong
Format: Final Year Project
Language:English
Published: 2009
Subjects:
Online Access:http://hdl.handle.net/10356/16639
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-166392023-03-03T15:34:06Z Formulation of micron-scale carrier particles of nanoparticulate drug : effects of nanoparticle size, chemical nature and concentration. Kok, Hui Hua. Kunn Hadinoto Ong School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering::Biotechnology Pulmonary delivery of the nanoparticles to the lungs serves as an attractive route due to the high solute permeability and large surface area for absorption. The nanoparticles are able to escape the phagocytic clearance mechanism in the lungs, but their small sizes often results in the particles being exhaled. Hence large hollow nanoparticles aggregates (LHNPA) are required. The desirable properties for the morphology of these LHNPA are obtained through the variations and investigations of three parameters namely the nanoparticle sizes, concentrations and chemical natures (silica and PMMA). The nanoparticles are then spray-dried and characterized under the Scanning Electron Microscope (SEM). Spray-drying low concentration levels such as 0.3-0.8% of nanoparticles are able to give spherical and hollow aggregates. In addition, it was found that large nanoparticle sizes are able to form thinner aggregates shell. However as the sizes of these nanoparticles reach micron-scale; they are unable to form LHNPA due to the similarities in sizes of the spray droplets. From the investigation of silica and PMMA, it was found that silica had a better morphology as compared to PMMA. The aggregate strength study on the silica particles also show that non-hollow and non-spherical particles are difficult to break. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2009-05-27T08:17:17Z 2009-05-27T08:17:17Z 2009 2009 Final Year Project (FYP) http://hdl.handle.net/10356/16639 en Nanyang Technological University 74 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Chemical engineering::Biotechnology
spellingShingle DRNTU::Engineering::Chemical engineering::Biotechnology
Kok, Hui Hua.
Formulation of micron-scale carrier particles of nanoparticulate drug : effects of nanoparticle size, chemical nature and concentration.
description Pulmonary delivery of the nanoparticles to the lungs serves as an attractive route due to the high solute permeability and large surface area for absorption. The nanoparticles are able to escape the phagocytic clearance mechanism in the lungs, but their small sizes often results in the particles being exhaled. Hence large hollow nanoparticles aggregates (LHNPA) are required. The desirable properties for the morphology of these LHNPA are obtained through the variations and investigations of three parameters namely the nanoparticle sizes, concentrations and chemical natures (silica and PMMA). The nanoparticles are then spray-dried and characterized under the Scanning Electron Microscope (SEM). Spray-drying low concentration levels such as 0.3-0.8% of nanoparticles are able to give spherical and hollow aggregates. In addition, it was found that large nanoparticle sizes are able to form thinner aggregates shell. However as the sizes of these nanoparticles reach micron-scale; they are unable to form LHNPA due to the similarities in sizes of the spray droplets. From the investigation of silica and PMMA, it was found that silica had a better morphology as compared to PMMA. The aggregate strength study on the silica particles also show that non-hollow and non-spherical particles are difficult to break.
author2 Kunn Hadinoto Ong
author_facet Kunn Hadinoto Ong
Kok, Hui Hua.
format Final Year Project
author Kok, Hui Hua.
author_sort Kok, Hui Hua.
title Formulation of micron-scale carrier particles of nanoparticulate drug : effects of nanoparticle size, chemical nature and concentration.
title_short Formulation of micron-scale carrier particles of nanoparticulate drug : effects of nanoparticle size, chemical nature and concentration.
title_full Formulation of micron-scale carrier particles of nanoparticulate drug : effects of nanoparticle size, chemical nature and concentration.
title_fullStr Formulation of micron-scale carrier particles of nanoparticulate drug : effects of nanoparticle size, chemical nature and concentration.
title_full_unstemmed Formulation of micron-scale carrier particles of nanoparticulate drug : effects of nanoparticle size, chemical nature and concentration.
title_sort formulation of micron-scale carrier particles of nanoparticulate drug : effects of nanoparticle size, chemical nature and concentration.
publishDate 2009
url http://hdl.handle.net/10356/16639
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