Endothelial damage and cardiac dysfunction in the pathophysiology of severe dengue in adults

Dengue infection is the most abundant arbovirus infection globally, affecting more than half the world’s population and is predicted to increase with climate change. Disease caused by the dengue virus ranges from asymptomatic to life threatening disease, and the main pathogenesis of severe dengue is...

Full description

Saved in:
Bibliographic Details
Main Author: Chia, Po Ying
Other Authors: Yeo Tsin Wen
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2023
Subjects:
Online Access:https://hdl.handle.net/10356/166502
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-166502
record_format dspace
spelling sg-ntu-dr.10356-1665022023-05-02T06:33:01Z Endothelial damage and cardiac dysfunction in the pathophysiology of severe dengue in adults Chia, Po Ying Yeo Tsin Wen Lee Kong Chian School of Medicine (LKCMedicine) yeotsinwen@ntu.edu.sg Science::Medicine Dengue infection is the most abundant arbovirus infection globally, affecting more than half the world’s population and is predicted to increase with climate change. Disease caused by the dengue virus ranges from asymptomatic to life threatening disease, and the main pathogenesis of severe dengue is increased vascular permeability resulting in shock and end-organ damage. Despite the global burden of disease, there is no specific treatment for dengue infection and only supportive care is available. There are also no biomarkers available to predict the severity of disease in early dengue illness. In this thesis, I present the results of a prospective observational study of dengue participants investigating the pathogenesis of dengue shock and potential upstream host mediators. Both vascular hyperpermeability and cardiac dysfunction were evaluated, along with potential neutrophil and mast cell mediators. The results of the study are then used to identify targets for further biomarker research and rational development of therapeutics. Doctor of Philosophy 2023-04-28T02:25:43Z 2023-04-28T02:25:43Z 2022 Thesis-Doctor of Philosophy Chia, P. Y. (2022). Endothelial damage and cardiac dysfunction in the pathophysiology of severe dengue in adults. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/166502 https://hdl.handle.net/10356/166502 10.32657/10356/166502 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
spellingShingle Science::Medicine
Chia, Po Ying
Endothelial damage and cardiac dysfunction in the pathophysiology of severe dengue in adults
description Dengue infection is the most abundant arbovirus infection globally, affecting more than half the world’s population and is predicted to increase with climate change. Disease caused by the dengue virus ranges from asymptomatic to life threatening disease, and the main pathogenesis of severe dengue is increased vascular permeability resulting in shock and end-organ damage. Despite the global burden of disease, there is no specific treatment for dengue infection and only supportive care is available. There are also no biomarkers available to predict the severity of disease in early dengue illness. In this thesis, I present the results of a prospective observational study of dengue participants investigating the pathogenesis of dengue shock and potential upstream host mediators. Both vascular hyperpermeability and cardiac dysfunction were evaluated, along with potential neutrophil and mast cell mediators. The results of the study are then used to identify targets for further biomarker research and rational development of therapeutics.
author2 Yeo Tsin Wen
author_facet Yeo Tsin Wen
Chia, Po Ying
format Thesis-Doctor of Philosophy
author Chia, Po Ying
author_sort Chia, Po Ying
title Endothelial damage and cardiac dysfunction in the pathophysiology of severe dengue in adults
title_short Endothelial damage and cardiac dysfunction in the pathophysiology of severe dengue in adults
title_full Endothelial damage and cardiac dysfunction in the pathophysiology of severe dengue in adults
title_fullStr Endothelial damage and cardiac dysfunction in the pathophysiology of severe dengue in adults
title_full_unstemmed Endothelial damage and cardiac dysfunction in the pathophysiology of severe dengue in adults
title_sort endothelial damage and cardiac dysfunction in the pathophysiology of severe dengue in adults
publisher Nanyang Technological University
publishDate 2023
url https://hdl.handle.net/10356/166502
_version_ 1765213845929852928