Functionalisation of extracellular vesicles for antibacterial applications
Cell-derived nanovesicles (CDNs) mimic biological counterparts, exosomes, in the ability to accumulate at disease sites with specificity. This makes CDNs ideal for drug delivery and the targeting and therapeutic efficiency can be improve by functionalization of these vesicles with antibacterial prop...
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| Format: | Final Year Project |
| Language: | English |
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Nanyang Technological University
2023
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| Online Access: | https://hdl.handle.net/10356/166626 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Cell-derived nanovesicles (CDNs) mimic biological counterparts, exosomes, in the ability to accumulate at disease sites with specificity. This makes CDNs ideal for drug delivery and the targeting and therapeutic efficiency can be improve by functionalization of these vesicles with antibacterial properties. This project aims to utilise Pseudomonas aeruginosa bacteria-derived natural and mimetic extracellular vesicles (EVs) as a medium to stimulate live adipose-derived mesenchymal stem cells (ADSCs) to produce antimicrobial proteins, and using those stimulated ADSCs to produce mimetic ADSC-EVs that will contain antibacterial properties as a result of stimulation. In this study, the antibacterial activity of the stimulated mimetic ADSC-EVs was evaluated against normal mimetic ADSC-EVs and found to have improved antibacterial properties against Pseudomonas aeruginosa. |
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