Study of secondary metabolite pathways that contribute to analgesic activity in three species of medicinal plants
Given the interest in medicinal plants that have potential pain-relieving effects without the side effects of NSAIDS and opioids, secondary metabolite pathways in plants are being studied extensively. However, there are several valuable compounds for which the biosynthetic pathways are yet to be...
Saved in:
Main Author: | |
---|---|
Other Authors: | |
Format: | Final Year Project |
Language: | English |
Published: |
Nanyang Technological University
2023
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/167088 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
id |
sg-ntu-dr.10356-167088 |
---|---|
record_format |
dspace |
spelling |
sg-ntu-dr.10356-1670882023-05-22T15:35:20Z Study of secondary metabolite pathways that contribute to analgesic activity in three species of medicinal plants Menon, Devika Marek Mutwil School of Biological Sciences mutwil@ntu.edu.sg Science::Biological sciences Given the interest in medicinal plants that have potential pain-relieving effects without the side effects of NSAIDS and opioids, secondary metabolite pathways in plants are being studied extensively. However, there are several valuable compounds for which the biosynthetic pathways are yet to be understood. Hence, the study aimed to investigate the relevant secondary metabolite pathways in three species of medicinal plants which are known to have analgesic properties - P. granatum, A. paniculata, T. divaricata. In P. granatum the pathways studied were flavenoid biosynthesis pathways and Anthocyanin biosynthesis pathways. For both these pathways, key enzymes were identified after annotation using E2P2 and PathoLogic on PathwayTools. Pathways in A. paniculata were studied similarly, but were focused on the synthesis of andrographolide. The pathways that lead to the synthesis of an andrographolide precursor were identified to have high frequency scores and the enzymes involved were identified as well. Finally, RNA samples of T.divaricata from a dwarf and wild-type plant were extracted and transcriptomes from two organs of the dwarf plant were assembled towards the pathway analysis. Bachelor of Science in Biological Sciences 2023-05-21T12:49:03Z 2023-05-21T12:49:03Z 2023 Final Year Project (FYP) Menon, D. (2023). Study of secondary metabolite pathways that contribute to analgesic activity in three species of medicinal plants. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/167088 https://hdl.handle.net/10356/167088 en application/pdf Nanyang Technological University |
institution |
Nanyang Technological University |
building |
NTU Library |
continent |
Asia |
country |
Singapore Singapore |
content_provider |
NTU Library |
collection |
DR-NTU |
language |
English |
topic |
Science::Biological sciences |
spellingShingle |
Science::Biological sciences Menon, Devika Study of secondary metabolite pathways that contribute to analgesic activity in three species of medicinal plants |
description |
Given the interest in medicinal plants that have potential pain-relieving effects without the side
effects of NSAIDS and opioids, secondary metabolite pathways in plants are being studied
extensively. However, there are several valuable compounds for which the biosynthetic
pathways are yet to be understood. Hence, the study aimed to investigate the relevant secondary
metabolite pathways in three species of medicinal plants which are known to have analgesic
properties - P. granatum, A. paniculata, T. divaricata. In P. granatum the pathways studied were
flavenoid biosynthesis pathways and Anthocyanin biosynthesis pathways. For both these
pathways, key enzymes were identified after annotation using E2P2 and PathoLogic on
PathwayTools. Pathways in A. paniculata were studied similarly, but were focused on the
synthesis of andrographolide. The pathways that lead to the synthesis of an andrographolide
precursor were identified to have high frequency scores and the enzymes involved were
identified as well. Finally, RNA samples of T.divaricata from a dwarf and wild-type plant were
extracted and transcriptomes from two organs of the dwarf plant were assembled towards the
pathway analysis. |
author2 |
Marek Mutwil |
author_facet |
Marek Mutwil Menon, Devika |
format |
Final Year Project |
author |
Menon, Devika |
author_sort |
Menon, Devika |
title |
Study of secondary metabolite pathways that contribute to analgesic activity in three species of medicinal plants |
title_short |
Study of secondary metabolite pathways that contribute to analgesic activity in three species of medicinal plants |
title_full |
Study of secondary metabolite pathways that contribute to analgesic activity in three species of medicinal plants |
title_fullStr |
Study of secondary metabolite pathways that contribute to analgesic activity in three species of medicinal plants |
title_full_unstemmed |
Study of secondary metabolite pathways that contribute to analgesic activity in three species of medicinal plants |
title_sort |
study of secondary metabolite pathways that contribute to analgesic activity in three species of medicinal plants |
publisher |
Nanyang Technological University |
publishDate |
2023 |
url |
https://hdl.handle.net/10356/167088 |
_version_ |
1772827422432952320 |