Ginsentide TP1 protects hypoxia-induced dysfunction and ER stress-linked apoptosis

• Main Authors: Dutta, Bamaprasad, Loo, Shining, Kam, Antony, Sze, Siu Kwan, Tam, James P.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Vascular Endothelial Dysfunction; Hypoxia; Ginsentide; ER Stress; Unfolded Protein Response; Antioxidation; Anti-Inflammation; Anti-Apoptosis; Pulsed SILAC; Quantitative Proteomics
• Online Access: https://hdl.handle.net/10356/167887
• Institution: Nanyang Technological University

Hypoxia-induced vascular endothelial dysfunction (VED) is a significant contributor to several severe human diseases, including heart disease, stroke, dementia, and cancer. However, current treatment options for VED are limited due to the lack of understanding of the underlying disease mechanisms an...