Development and characterisation of a nanoparticle-based sensor & microneedle-based sensor for codeine monitoring

• Main Author: Zhang, Haihui
• Other Authors: Poenar Daniel Puiu
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2023
• Subjects: Engineering::Electrical and electronic engineering
• Online Access: https://hdl.handle.net/10356/167942
• Institution: Nanyang Technological University

Drug addiction is a significant global public health concern, with codeine abuse being a leading contributor to this issue. The effective monitoring and control of opioids necessitates the development of rapid, sensitive, and specific detection techniques. This report aims to confirm the efficacy of nanoparticle-based sensors with modified screen-printed carbon electrodes and microneedle-based sensors for monitoring codeine. In this investigation, we utilized modified screen-printed electrodes as highly specific and sensitive electrochemical sensors to quantify codeine using differential pulse voltammetry. Our results indicate a detection limit of 0.0005 μM, a linear range of 0.0005-0.005 μM, and favorable selectivity between AA(Ascorbic acid) and UA (Uric acid). Additionally, we investigated the sensor's performance when combined with a microneedle system.