Artificial metalloenzymes from bovine β-lactoglobulin and transition metal N-functionalised N-heterocyclic carbene cofactors
Drawing inspiration from natural metalloenzymes such as hydrogenases and nitrogenases and being involved in many biological processes, artificial metalloenzymes involve the assembly of synthetic metal cofactors to a protein host to create biohybrids having tailored catalytic activity. A series of...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2023
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| Online Access: | https://hdl.handle.net/10356/168536 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Drawing inspiration from natural metalloenzymes such as hydrogenases and nitrogenases
and being involved in many biological processes, artificial metalloenzymes involve the
assembly of synthetic metal cofactors to a protein host to create biohybrids having tailored
catalytic activity. A series of N-functionalised N-heterocyclic carbene (NHC) metal complexes
featuring long aliphatic carbon chains has been synthesized and their subsequent assembly to
bovine β-lactoglobulin, a protein found in the whey fraction of milk, was investigated. The
catalytic potential of both the NHC-metal cofactors and bioconjugates was studied via the hydroarylation of a pro-fluorescent substrate. |
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