Research advance of natural products in tumor immunotherapy
Cancer immunotherapy has emerged as a novel anti-tumor treatment. Despite significant breakthroughs, cancer immunotherapy remains focused on several types of tumors that are sensitive to the immune system. Therefore, effective strategies to expand its indications and improve its efficacy become key...
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sg-ntu-dr.10356-1685782023-06-10T16:47:52Z Research advance of natural products in tumor immunotherapy Huo, Jin-Ling Fu, Wen-Jia Liu, Zheng-Han Lu, Nan Jia, Xiang-Qian Liu, Zhang-Suo School of Mechanical and Aerospace Engineering Science::Medicine Tumor Immunotherapy Immune Cells Cancer immunotherapy has emerged as a novel anti-tumor treatment. Despite significant breakthroughs, cancer immunotherapy remains focused on several types of tumors that are sensitive to the immune system. Therefore, effective strategies to expand its indications and improve its efficacy become key factors for the further development of cancer immunotherapy. In recent decades, the anticancer activities of natural products are reported to have this effect on cancer immunotherapy. And the mechanism is largely attributed to the remodeling of the tumor immunosuppressive microenvironment. The compelling data highlight that natural products offer an alternative method option to improve immune function in the tumor microenvironment (TME). Currently, more attention is being paid to the discovery of new potential modulators of tumor immunotherapy from natural products. In this review, we describe current advances in employing natural products and natural small-molecule drugs targeting immune cells to avoid tumor immune escape, which may bring some insight for guiding tumor treatment. Published version This work was financially supported by General Program of the National Natural Science Foundation of China Joint project (NO. U21A20348), National Natural Science Foundation of China General Project (No.81970633), Heilongjiang Provincial Higher Education Institutions Basic Research Business Expenses (2021KYYWF0046). 2023-06-06T06:12:45Z 2023-06-06T06:12:45Z 2022 Journal Article Huo, J., Fu, W., Liu, Z., Lu, N., Jia, X. & Liu, Z. (2022). Research advance of natural products in tumor immunotherapy. Frontiers in Immunology, 13, 972345-. https://dx.doi.org/10.3389/fimmu.2022.972345 1664-3224 https://hdl.handle.net/10356/168578 10.3389/fimmu.2022.972345 36159787 2-s2.0-85138545782 13 972345 en Frontiers in Immunology © 2022 Huo, Fu, Liu, Lu, Jia and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
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Science::Medicine Tumor Immunotherapy Immune Cells Huo, Jin-Ling Fu, Wen-Jia Liu, Zheng-Han Lu, Nan Jia, Xiang-Qian Liu, Zhang-Suo Research advance of natural products in tumor immunotherapy |
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Cancer immunotherapy has emerged as a novel anti-tumor treatment. Despite significant breakthroughs, cancer immunotherapy remains focused on several types of tumors that are sensitive to the immune system. Therefore, effective strategies to expand its indications and improve its efficacy become key factors for the further development of cancer immunotherapy. In recent decades, the anticancer activities of natural products are reported to have this effect on cancer immunotherapy. And the mechanism is largely attributed to the remodeling of the tumor immunosuppressive microenvironment. The compelling data highlight that natural products offer an alternative method option to improve immune function in the tumor microenvironment (TME). Currently, more attention is being paid to the discovery of new potential modulators of tumor immunotherapy from natural products. In this review, we describe current advances in employing natural products and natural small-molecule drugs targeting immune cells to avoid tumor immune escape, which may bring some insight for guiding tumor treatment. |
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School of Mechanical and Aerospace Engineering |
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School of Mechanical and Aerospace Engineering Huo, Jin-Ling Fu, Wen-Jia Liu, Zheng-Han Lu, Nan Jia, Xiang-Qian Liu, Zhang-Suo |
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Article |
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Huo, Jin-Ling Fu, Wen-Jia Liu, Zheng-Han Lu, Nan Jia, Xiang-Qian Liu, Zhang-Suo |
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Huo, Jin-Ling |
title |
Research advance of natural products in tumor immunotherapy |
title_short |
Research advance of natural products in tumor immunotherapy |
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Research advance of natural products in tumor immunotherapy |
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Research advance of natural products in tumor immunotherapy |
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Research advance of natural products in tumor immunotherapy |
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research advance of natural products in tumor immunotherapy |
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2023 |
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https://hdl.handle.net/10356/168578 |
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