Bioorthogonally activatable cyanine dye with torsion-induced disaggregation for in vivo tumor imaging

• Main Authors: Zhang, Xianghan, Gao, Jingkai, Tang, Yingdi, Yu, Jie, Liew, Si Si, Qiao, Chaoqiang, Cao, Yutian, Liu, Guohuan, Fan, Hongyu, Xia, Yuqiong, Tian, Jie, Pu, Kanyi, Wang, Zhongliang
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Chemical engineering; Cyanine Dye; Nitrogen
• Online Access: https://hdl.handle.net/10356/168645
• Institution: Nanyang Technological University

Advancement of bioorthogonal chemistry in molecular optical imaging lies in expanding the repertoire of fluorophores that can undergo fluorescence signal changes upon bioorthogonal ligation. However, most available bioorthogonally activatable fluorophores only emit shallow tissue-penetrating visible...