Nanozyme-reinforced hydrogel as a H₂O₂-driven oxygenerator for enhancing prosthetic interface osseointegration in rheumatoid arthritis therapy

• Main Authors: Zhao, Yue, Song, Shanliang, Wang, Dongdong, Liu, He, Zhang, Junmin, Li, Zuhao, Wang, Jincheng, Ren, Xiangzhong, Zhao, Yanli
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Catalase; Dissolved Oxygen
• Online Access: https://hdl.handle.net/10356/168650
• Institution: Nanyang Technological University

Stem cell-based therapy has drawn attention for enhancing the osseointegration efficiency after joint replacement in the rheumatoid arthritis (RA). However, therapeutic efficacy of this approach is threatened by the accumulated reactive oxygen species (ROS) and poor oxygen supply. Herein, we develop...