Asymmetric synthesis of S(IV) and S(VI) stereogenic centers

Asymmetric synthesis of S(IV) and S(VI) stereogenic centers

Sulfur can form diverse S(IV) and S(VI) stereogenic centers, of which some have gained significant attention recently due to their increasing use as pharmacophores in drug discovery programs. The preparation of these sulfur stereogenic centers in their enantiopure form has been challenging, and prog...

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Main Authors: Zhang, Xin, Wang, Fucheng, Tan, Choon-Hong
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2023
Subjects:
Science::Chemistry
Asymmetric Synthesis
Stereogenic Centers
Online Access:https://hdl.handle.net/10356/168722
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1687222023-06-16T15:31:47Z Asymmetric synthesis of S(IV) and S(VI) stereogenic centers Zhang, Xin Wang, Fucheng Tan, Choon-Hong School of Chemistry, Chemical Engineering and Biotechnology Science::Chemistry Asymmetric Synthesis Stereogenic Centers Sulfur can form diverse S(IV) and S(VI) stereogenic centers, of which some have gained significant attention recently due to their increasing use as pharmacophores in drug discovery programs. The preparation of these sulfur stereogenic centers in their enantiopure form has been challenging, and progress made will be discussed in this Perspective. This Perspective summarizes different strategies, with selected works, for asymmetric synthesis of these moieties, including diastereoselective transformations using chiral auxiliaries, enantiospecific transformations of enantiopure sulfur compounds, and catalytic enantioselective synthesis. We will discuss the advantages and limitations of these strategies and will provide our views on how this field will develop. Nanyang Technological University Published version X.Z. acknowledges financial support from the start-up funding from Sichuan University. C.H.T. acknowledges financial support from Nanyang Technological University (Tier 1 RG2/20). 2023-06-16T05:59:17Z 2023-06-16T05:59:17Z 2023 Journal Article Zhang, X., Wang, F. & Tan, C. (2023). Asymmetric synthesis of S(IV) and S(VI) stereogenic centers. JACS Au, 3(3), 700-714. https://dx.doi.org/10.1021/jacsau.2c00626 2691-3704 https://hdl.handle.net/10356/168722 10.1021/jacsau.2c00626 37006767 2-s2.0-85149117315 3 3 700 714 en RG2/20 JACS Au © 2023 The Authors. Published by American Chemical Society. This is an open-access article distributed under the terms of the Creative Commons Attribution License. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Asymmetric Synthesis
Stereogenic Centers
spellingShingle Science::Chemistry
Asymmetric Synthesis
Stereogenic Centers
Zhang, Xin
Wang, Fucheng
Tan, Choon-Hong
Asymmetric synthesis of S(IV) and S(VI) stereogenic centers
description Sulfur can form diverse S(IV) and S(VI) stereogenic centers, of which some have gained significant attention recently due to their increasing use as pharmacophores in drug discovery programs. The preparation of these sulfur stereogenic centers in their enantiopure form has been challenging, and progress made will be discussed in this Perspective. This Perspective summarizes different strategies, with selected works, for asymmetric synthesis of these moieties, including diastereoselective transformations using chiral auxiliaries, enantiospecific transformations of enantiopure sulfur compounds, and catalytic enantioselective synthesis. We will discuss the advantages and limitations of these strategies and will provide our views on how this field will develop.
author2 School of Chemistry, Chemical Engineering and Biotechnology
author_facet School of Chemistry, Chemical Engineering and Biotechnology
Zhang, Xin
Wang, Fucheng
Tan, Choon-Hong
format Article
author Zhang, Xin
Wang, Fucheng
Tan, Choon-Hong
author_sort Zhang, Xin
title Asymmetric synthesis of S(IV) and S(VI) stereogenic centers
title_short Asymmetric synthesis of S(IV) and S(VI) stereogenic centers
title_full Asymmetric synthesis of S(IV) and S(VI) stereogenic centers
title_fullStr Asymmetric synthesis of S(IV) and S(VI) stereogenic centers
title_full_unstemmed Asymmetric synthesis of S(IV) and S(VI) stereogenic centers
title_sort asymmetric synthesis of s(iv) and s(vi) stereogenic centers
publishDate 2023
url https://hdl.handle.net/10356/168722
_version_ 1772826725006180352

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