Impaired episodic-like memory in a mouse model of Alzheimer's disease is associated with hyperactivity in prefrontal-hippocampal regions

• Main Authors: Tan, Sijie, Tong, Wen Han, Vyas, Ajai
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Dementia; Episodic Memory
• Online Access: https://hdl.handle.net/10356/168843
• Institution: Nanyang Technological University

Alzheimer's disease (AD) is a degenerative brain disorder with a long prodromal period. An APPNL-G-F knock-in mouse model is a preclinical model to study incipient pathologies during the early stages of AD. Despite behavioral tests revealing broad cognitive deficits in APPNL-G-F mice, detecting...