Gut microbiota in colorectal cancer: biological role and therapeutic opportunities

Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths worldwide. While CRC is thought to be an interplay between genetic and environmental factors, several lines of evidence suggest the involvement of gut microbiota in promoting inflammation and tumor progression. Gut microbio...

Full description

Saved in:
Bibliographic Details
Main Authors: Pandey, Himani, Tang, Daryl W. T., Wong, Sunny Hei, Lal, Devi
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2023
Subjects:
Online Access:https://hdl.handle.net/10356/168844
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-168844
record_format dspace
spelling sg-ntu-dr.10356-1688442023-06-25T15:37:39Z Gut microbiota in colorectal cancer: biological role and therapeutic opportunities Pandey, Himani Tang, Daryl W. T. Wong, Sunny Hei Lal, Devi School of Biological Sciences Lee Kong Chian School of Medicine (LKCMedicine) Centre for Microbiome Medicine Science::Biological sciences Colorectal Cancer Microbiota Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths worldwide. While CRC is thought to be an interplay between genetic and environmental factors, several lines of evidence suggest the involvement of gut microbiota in promoting inflammation and tumor progression. Gut microbiota refer to the ~40 trillion microorganisms that inhabit the human gut. Advances in next-generation sequencing technologies and metagenomics have provided new insights into the gut microbial ecology and have helped in linking gut microbiota to CRC. Many studies carried out in humans and animal models have emphasized the role of certain gut bacteria, such as Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, and colibactin-producing Escherichia coli, in the onset and progression of CRC. Metagenomic studies have opened up new avenues for the application of gut microbiota in the diagnosis, prevention, and treatment of CRC. This review article summarizes the role of gut microbiota in CRC development and its use as a biomarker to predict the disease and its potential therapeutic applications. Nanyang Technological University Published version The authors would like to acknowledge the NTU Start Up Grant (021337-00001) (S.W.) and the Wang Lee Wah Memorial Fund for support of this work. 2023-06-20T05:25:41Z 2023-06-20T05:25:41Z 2023 Journal Article Pandey, H., Tang, D. W. T., Wong, S. H. & Lal, D. (2023). Gut microbiota in colorectal cancer: biological role and therapeutic opportunities. Cancers, 15(3), 866-. https://dx.doi.org/10.3390/cancers15030866 2072-6694 https://hdl.handle.net/10356/168844 10.3390/cancers15030866 36765824 2-s2.0-85147803329 3 15 866 en NTU-SUG (021337-00001) Cancers © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Biological sciences
Colorectal Cancer
Microbiota
spellingShingle Science::Biological sciences
Colorectal Cancer
Microbiota
Pandey, Himani
Tang, Daryl W. T.
Wong, Sunny Hei
Lal, Devi
Gut microbiota in colorectal cancer: biological role and therapeutic opportunities
description Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths worldwide. While CRC is thought to be an interplay between genetic and environmental factors, several lines of evidence suggest the involvement of gut microbiota in promoting inflammation and tumor progression. Gut microbiota refer to the ~40 trillion microorganisms that inhabit the human gut. Advances in next-generation sequencing technologies and metagenomics have provided new insights into the gut microbial ecology and have helped in linking gut microbiota to CRC. Many studies carried out in humans and animal models have emphasized the role of certain gut bacteria, such as Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, and colibactin-producing Escherichia coli, in the onset and progression of CRC. Metagenomic studies have opened up new avenues for the application of gut microbiota in the diagnosis, prevention, and treatment of CRC. This review article summarizes the role of gut microbiota in CRC development and its use as a biomarker to predict the disease and its potential therapeutic applications.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Pandey, Himani
Tang, Daryl W. T.
Wong, Sunny Hei
Lal, Devi
format Article
author Pandey, Himani
Tang, Daryl W. T.
Wong, Sunny Hei
Lal, Devi
author_sort Pandey, Himani
title Gut microbiota in colorectal cancer: biological role and therapeutic opportunities
title_short Gut microbiota in colorectal cancer: biological role and therapeutic opportunities
title_full Gut microbiota in colorectal cancer: biological role and therapeutic opportunities
title_fullStr Gut microbiota in colorectal cancer: biological role and therapeutic opportunities
title_full_unstemmed Gut microbiota in colorectal cancer: biological role and therapeutic opportunities
title_sort gut microbiota in colorectal cancer: biological role and therapeutic opportunities
publishDate 2023
url https://hdl.handle.net/10356/168844
_version_ 1772828668489367552