Waffle-inspired hydrogel-based macrodevice for spatially controlled distribution of encapsulated therapeutic microtissues and pro-angiogenic endothelial cells

• Main Authors: Pham, Chi H. L., Zuo, Yicong, Chen, Yang, Tran, Nam M., Nguyen, Dang T., Dang, Tram T.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Bioengineering; Diabetes; Homogeneous Distribution
• Online Access: https://hdl.handle.net/10356/168878
• Institution: Nanyang Technological University

Macro-encapsulation systems for delivery of cellular therapeutics in diabetes treatment offer major advantages such as device retrievability and high cell packing density. However, microtissue aggregation and absence of vasculature have been implicated in the inadequate transfer of nutrients and oxy...