Stereodirecting effects of 4-O-ortho-cyanobenzyl ether on chemical glycosylation with glucopyranosyl donor

• Main Authors: Zhang, Han, Guo, Aoxin, Meng, Youhui, Wang, Yue, Gao, Jian, Liu, Xue-Wei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Glycosylation; Oligosaccharides
• Online Access: https://hdl.handle.net/10356/168881
• Institution: Nanyang Technological University

Here we report a systematic investigation on the stereodirecting effects of a 4-O-ortho-cyanobenzyl ether (oBCN) group with a glucopyranosyl donor. Experimental studies revealed that the glycosylation reactions using this donor generally show dual-stereoselectivities depending on the acceptor nucleo...