Engineered drug delivery nanosystems for tumor microenvironment normalization therapy
As a complex “soil” ecosystem, the tumor microenvironment (TME) plays a crucial role in the occurrence, development and metastasis of tumors. Reprogramming TME can block the interactive network between tumors and extracellular matrix (ECM) / various surrounding cells and contribute to tumor effectiv...
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sg-ntu-dr.10356-1689102023-06-22T03:52:18Z Engineered drug delivery nanosystems for tumor microenvironment normalization therapy Yang, Beining Meng, Fanze Zhang, Jihao Chen, Kerun Meng, Siyu Cai, Kaiyong Zhao, Yanli Dai, Liangliang School of Chemistry, Chemical Engineering and Biotechnology Engineering::Chemical engineering Engineered Drug Delivery Nanosystems Normalization of Tumor Microenvironment As a complex “soil” ecosystem, the tumor microenvironment (TME) plays a crucial role in the occurrence, development and metastasis of tumors. Reprogramming TME can block the interactive network between tumors and extracellular matrix (ECM) / various surrounding cells and contribute to tumor effective damage, which is a potential therapeutic target in oncotherapy. Nanobiomaterials have received more attention due to their excellent drug loading and easy functionalization properties, which have been extensively integrated into the construction of engineered drug delivery nanosystems for TME normalization therapy. It has become a commanding point in the field of anti-tumor therapy. This review intends to present and analyze advanced nanotechnology strategies for normalizing TME from 7 different aspects including the reprogramming of extracellular matrix (ECM), cancer-associated fibroblasts (CAFs), abnormal blood vasculatures, hypoxia, tumor acidosis, tumor-associated macrophages (TAMs) and tumor immune tolerance microenvironment based on the various engineered drug delivery nanosystems. It also discusses the currently existing problems and future development trends, which are expected to be helpful for the translational application of nanomedicine in clinical cancer therapy. This work was financially supported by the National Natural Science Foundation of China (51303218, 51825302, 11472224, 11672246, 11722220, 21274169 and 81760441), the National Key Research and Development Program of China (2016YFC1100300 and 2017YFB0702603), the Fundamental Research Funds for the Central Universities (G2018KY0302 and 3102019YX01003), and the Natural Science Foundation of Shaanxi Province (2019JQ-347). 2023-06-22T03:52:18Z 2023-06-22T03:52:18Z 2023 Journal Article Yang, B., Meng, F., Zhang, J., Chen, K., Meng, S., Cai, K., Zhao, Y. & Dai, L. (2023). Engineered drug delivery nanosystems for tumor microenvironment normalization therapy. Nano Today, 49, 101766-. https://dx.doi.org/10.1016/j.nantod.2023.101766 1748-0132 https://hdl.handle.net/10356/168910 10.1016/j.nantod.2023.101766 2-s2.0-85149711620 49 101766 en Nano Today © 2023 Elsevier Ltd. All rights reserved. |
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Engineering::Chemical engineering Engineered Drug Delivery Nanosystems Normalization of Tumor Microenvironment Yang, Beining Meng, Fanze Zhang, Jihao Chen, Kerun Meng, Siyu Cai, Kaiyong Zhao, Yanli Dai, Liangliang Engineered drug delivery nanosystems for tumor microenvironment normalization therapy |
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As a complex “soil” ecosystem, the tumor microenvironment (TME) plays a crucial role in the occurrence, development and metastasis of tumors. Reprogramming TME can block the interactive network between tumors and extracellular matrix (ECM) / various surrounding cells and contribute to tumor effective damage, which is a potential therapeutic target in oncotherapy. Nanobiomaterials have received more attention due to their excellent drug loading and easy functionalization properties, which have been extensively integrated into the construction of engineered drug delivery nanosystems for TME normalization therapy. It has become a commanding point in the field of anti-tumor therapy. This review intends to present and analyze advanced nanotechnology strategies for normalizing TME from 7 different aspects including the reprogramming of extracellular matrix (ECM), cancer-associated fibroblasts (CAFs), abnormal blood vasculatures, hypoxia, tumor acidosis, tumor-associated macrophages (TAMs) and tumor immune tolerance microenvironment based on the various engineered drug delivery nanosystems. It also discusses the currently existing problems and future development trends, which are expected to be helpful for the translational application of nanomedicine in clinical cancer therapy. |
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School of Chemistry, Chemical Engineering and Biotechnology |
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School of Chemistry, Chemical Engineering and Biotechnology Yang, Beining Meng, Fanze Zhang, Jihao Chen, Kerun Meng, Siyu Cai, Kaiyong Zhao, Yanli Dai, Liangliang |
format |
Article |
author |
Yang, Beining Meng, Fanze Zhang, Jihao Chen, Kerun Meng, Siyu Cai, Kaiyong Zhao, Yanli Dai, Liangliang |
author_sort |
Yang, Beining |
title |
Engineered drug delivery nanosystems for tumor microenvironment normalization therapy |
title_short |
Engineered drug delivery nanosystems for tumor microenvironment normalization therapy |
title_full |
Engineered drug delivery nanosystems for tumor microenvironment normalization therapy |
title_fullStr |
Engineered drug delivery nanosystems for tumor microenvironment normalization therapy |
title_full_unstemmed |
Engineered drug delivery nanosystems for tumor microenvironment normalization therapy |
title_sort |
engineered drug delivery nanosystems for tumor microenvironment normalization therapy |
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2023 |
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https://hdl.handle.net/10356/168910 |
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