Targeting the alphavirus virus replication process for antiviral development

• Main Authors: Tan, Yaw Bia, Law, Michelle Cheok Yien, Luo, Dahai
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Science::Biological sciences; Alphavirus; Replication Complex
• Online Access: https://hdl.handle.net/10356/168999
• Institution: Nanyang Technological University

Many alphaviruses, including chikungunya virus (CHIKV) are known human pathogens that lack specific and effective antivirals or vaccines available. The upstream portion of the positive-sense single-stranded RNA genome of alphaviruses encodes four nonstructural proteins: nsP1 to nsP4. They are expres...