Understanding antibody-dependent enhancement in dengue: are afucosylated IgG1s a concern?

• Main Authors: Teo, Andrew, Tan, Hao Dong, Loy, Thomas, Chia, Po Ying, Chua, Caroline Lin Lin
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Fucosylation; FUT8
• Online Access: https://hdl.handle.net/10356/169169
• Institution: Nanyang Technological University

Dengue is a mosquito-borne infection caused by dengue virus (DENV) of the Flaviviridae family. There are four distinct serotypes, DENV-1,-2,-3,-4, which cause outbreaks globally. Infection is often self-resolving, and lifelong immunity against the infecting serotype can be achieved after exposure. H...