The role of receptor uniformity in multivalent binding

• Main Authors: Xia, Xiuyang, Zhang, Ge, Ciamarra, Pica Massimo, Jiao, Yang, Ni, Ran
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Chemical engineering; Engineering::Bioengineering; Multivalent Nanoparticle Binding; Superselectivity
• Online Access: https://hdl.handle.net/10356/169307
• Institution: Nanyang Technological University

Multivalency is prevalent in various biological systems and applications due to the superselectivity that arises from the cooperativity of multivalent binding. Traditionally, it was thought that weaker individual binding would improve the selectivity in multivalent targeting. Here, using analytical...