Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at primary cilia and regulates ciliary length and signaling

• Main Authors: Morthorst, Stine Kjær, Nielsen, Camilla, Farinelli, Pietro, Anvarian, Zeinab, Rasmussen, Christina Birgitte R., Serra-Marques, Andrea, Grigoriev, Ilya, Altelaar, Maarten, Fürstenberg, Nicoline, Ludwig, Alexander, Akhmanova, Anna, Christensen, Søren Tvorup, Pedersen, Lotte Bang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Angiomotin p80; KIF13B
• Online Access: https://hdl.handle.net/10356/169367
• Institution: Nanyang Technological University

The kinesin-3 motor KIF13B functions in endocytosis, vesicle transport and regulation of ciliary length and signaling. Direct binding of the membrane-associated guanylate kinase (MAGUK) DLG1 to the MAGUK-binding stalk domain of KIF13B relieves motor autoinhibition and promotes microtubule plus-end-d...