A targeted multi-proteomics approach generates a blueprint of the ciliary ubiquitinome

• Main Authors: Aslanyan, Mariam G., Doornbos, Cenna, Diwan, Gaurav D., Anvarian, Zeinab, Beyer, Tina, Junger, Katrin, van Beersum, Sylvia E. C., Russell, Robert B., Ueffing, Marius, Ludwig, Alexander, Boldt, Karsten, Pedersen, Lotte B., Roepman, Ronald
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Cilia; Clathrin-Mediated Endocytosis
• Online Access: https://hdl.handle.net/10356/169371
• Institution: Nanyang Technological University

Establishment and maintenance of the primary cilium as a signaling-competent organelle requires a high degree of fine tuning, which is at least in part achieved by a variety of post-translational modifications. One such modification is ubiquitination. The small and highly conserved ubiquitin protein...