Applications of genomics and transcriptomics in precision medicine for myopia control or prevention

• Main Authors: Jiang, Liqin, Goh, Dong Xuan, Koh, James Hao Zhong, Chan, Xavier, Brennan, Noel A., Barathi, Veluchamy Amutha, Hoang, Quan V
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Myopia; Molecular
• Online Access: https://hdl.handle.net/10356/169384
• Institution: Nanyang Technological University

Myopia is a globally emerging concern accompanied by multiple medical and socio-economic burdens with no well-established causal treatment to control thus far. The study of the genomics and transcriptomics of myopia treatment is crucial to delineate disease pathways and provide valuable insights for the design of precise and effective therapeutics. A strong understanding of altered biochemical pathways and underlying pathogenesis leading to myopia may facilitate early diagnosis and treatment of myopia, ultimately leading to the development of more effective preventive and therapeutic measures. In this review, we summarize current data about the genomics and transcriptomics of myopia in human and animal models. We also discuss the potential applicability of these findings to precision medicine for myopia treatment.