Favorable preclinical pharmacological profile of a novel antimalarial pyrrolizidinylmethyl derivative of 4-amino-7-chloroquinoline with potent In vitro and In vivo activities

• Main Authors: Basilico, Nicoletta, Parapini, Silvia, D'Alessandro, Sarah, Misiano, Paola, Romeo, Sergio, Dondio, Giulio, Yardley, Vanessa, Vivas, Livia, Nasser, Shereen, Renia, Laurent, Russell, Bruce, Suwanarusk, Rossarin, Nosten, François, Sparatore, Anna, Taramelli, Donatella
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Malaria; Drug Discovery
• Online Access: https://hdl.handle.net/10356/169386
• Institution: Nanyang Technological University

The 4-aminoquinoline drugs, such as chloroquine (CQ), amodiaquine or piperaquine, are still commonly used for malaria treatment, either alone (CQ) or in combination with artemisinin derivatives. We previously described the excellent in vitro activity of a novel pyrrolizidinylmethyl derivative of 4-a...