The combined effects of topography and stiffness on neuronal differentiation and maturation using a hydrogel platform

• المؤلفون الرئيسيون: Mattiassi, Sabrina, Conner, Abigail A., Feng, Fan, Goh, Eyleen Lay Keow, Yim, Evelyn K. F.
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Medicine; Neuronal Differentiation; Mechanobiology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/169490
• المؤسسة: Nanyang Technological University

Biophysical parameters such as substrate topography and stiffness have been shown independently to elicit profound effects on neuronal differentiation and maturation from neural progenitor cells (NPCs) yet have not been investigated in combination. Here, the effects of various micrograting and stiff...