Conditional knockout of hypoxia-inducible factor 1-alpha in tumor-infiltrating neutrophils protects against pancreatic ductal adenocarcinoma

• Main Authors: Sieow, Je Lin, Leong, Penny Hweixian, Gun, Sin Yee, Tan, Ling Qiao, Duan, Kaibo, Yeong, Joe Poh Sheng, Pang, Angela, Lim, Diana, Toh, Han Chong, Lim, Tony Kiat Hon, Engleman, Edgar, Rotzschke, Olaf, Ng, Lai Guan, Chen, Jinmiao, Tan, Suet Mien, Wong, Siew Cheng
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Neutrophils; Pancreatic Cancer
• Online Access: https://hdl.handle.net/10356/169561
• Institution: Nanyang Technological University

Large numbers of neutrophils infiltrate tumors and comprise a notable component of the inflammatory tumor microenvironment. While it is established that tumor cells exhibit the Warburg effect for energy production, the contribution of the neutrophil metabolic state to tumorigenesis is unknown. Here,...